Neurons May Live for Decades with Neurofibrillary Tangles
نویسندگان
چکیده
منابع مشابه
Neurofibrillary tangles may interfere with Smad 2/3 signaling in neurons.
Transforming growth factor (TGF)-beta is a multifunctional cytokine with anti-inflammatory, reparative and neuroprotective functions. Increased levels of TGFbeta in Alzheimer disease (AD) are associated with perivascular deposition of extracellular matrix, which may impair clearance of beta-amyloid and contribute to the development of cerebral amyloid angiopathy. TGFbeta signaling is transduced...
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Neurodegenerative disorders are characterized clinically by insidious onset and slowly progressive course, and are frequently hereditary. Pathologically, these diseases share a common feature: the selective loss of a particular subset of neurons for unknown reasons [e.g. cerebral cortical neurons in ALZHEIMER’S DISEASE (AD) (see Glossary), substantia nigra neurons in PARKINSON’S DISEASE (PD), s...
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The term "diffuse neurofibrillary tangles with calcification" (DNTC) is proposed for a new form of presenile dementia. It is characterised by slowly progressive cortical dementia in the presenium, localised temporal or temporofrontal lobar atrophy, numerous neurofibrillary tangles widespread in the cerebral cortex, and pronounced calcareous deposits; 16 cases of DNTC, have been reported.
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The two pathognomonic lesions in the brain of AD patients are senile plaques and intraneuronal neurofibrillary tangles (NFT). Previous studies have demonstrated that amyloid-β (Aβ) is a component of both senile plaques and NFTs, and have showed that intracellular accumulation of Aβ is toxic for cells and precedes the appearance of extracellular amyloid deposits. Here we report that there are nu...
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Alzheimer's disease is a major cause of dementia for which treatments remain unsatisfactory. Cyclin-dependent kinase 5 (CDK5) is a relevant kinase that has been hypothesized to contribute to the tau pathology. Several classes of chemical inhibitors for CDK5 have been developed, but they generally lack the specificity to distinguish among various ATP-dependent kinases. Therefore, the efficacy of...
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ژورنال
عنوان ژورنال: Journal of Neuropathology and Experimental Neurology
سال: 1999
ISSN: 0022-3069
DOI: 10.1097/00005072-199902000-00008